Endocrine Abstracts

Pseudoacromegaly is a rare disorder characterized by cutaneous manifestations of growth hormone excess but with normal growth hormone levels or IGF-1. This condition described in patients with insulin resistance, hypothyroidism, pachydermoperiostitis and drug intake such as minoxidil. The hyperinsulinaemia impaired metabolic signalling may activate intact mitogenic signalling pathways and stimulate pathological tissue growth.A 41-year-old man presented w...

Aim: The incidence of nodular thyroid disease is high among patients with insulin resistance. The aim of this study is to evaluate the relationship between BRAFV600E mutation and insulin resistance in the patients with papillary thyroid cancer.Materials and methods: We examined clinical and laboratory data of 103 patients who had been followed up by our department between the years 2010 and 2015. The diagnosis of insulin resistance (IR) was made when the...

Aim: BRAF is one of the serine threonin kinases that activates mitogen activated protein kinase (MAPK) signal pathway.The aim of this study is to evaluatethe relationship between extrathyroidal extension (ETE) and BRAFV600E mutation in the subjects with papillary thyroid cancer.Materials and methods: Clinical and laboratory data of 455 patients, who had been followed-up in our clinic between the years 2010 and 2015 for PTC, were evaluated. The relationsh...

Papillary thyroid cancer (PTC) constitutes 85% of all differentiated thyroid cancers. PTC is usually sporadic, but may occur in a familial form. Familial cancer syndromes such as Cowden’s syndrome and familial adenomatous polyposis are associated with PTC. Lal et al. recently published a study in which subsequent thyroid cancer was most common among the patients with renal cell cancer (RCC). RCC is a common malignancy of uroepithelial region, which constitutes about 3% of...